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In this review, we discuss pathways involved in pain sensing and processing primarily at the level of dorsal root ganglion (DRG) neurons and the potential interplay between vitamin D, its receptor (VDR) and known specific pain signaling pathways including nerve growth factor (NGF), glial-derived neurotrophic factor (GDNF), epidermal growth factor receptor (EGFR), and opioid receptors. However, the potential underlying mechanisms by which vitamin D might exert its analgesic effects are poorly understood. A strong correlation between hypovitaminosis D and incidence of bone pain is known.

Vitamin D, known for its role in calcium homeostasis and bone metabolism, is thought to be of clinical benefit in treating chronic pain without the side-effects of currently available analgesics. It is a complex disease in its own right for which currently available analgesics have been deemed woefully inadequate since ~20% of the sufferers derive no benefit. adult population suffer from chronic pain.

College of Medicine, QU Health, Qatar University, Doha, QatarĪbout 50 million of the U.S.

Habib *, Karim Nagi, Nagendra Babu Thillaiappan, VijayaKumar Sukumaran and Saghir Akhtar *

Vitamin D and Regulation OF OPIOID SignalingĪbdella M.

EGFR Signaling in Pain Processing: Interplay With Vitamin D?.

The Interplay Between NGF and Vitamin D in Pain Signaling.

Vitamin D and VDR in Pain Signal Transduction.

VDR and Vitamin D Regulating Enzymes Expression in Tissues Involved in Pain Signaling Pathways.

Vitamin D and VDR in Pain Signaling Pathways.

Sensitization- Interplay Between Immune and Neuronal Cells.Visceral Pain, Vitamin D and Gut Microbiota.Does Vitamin D PLay a Role in Sensing Pain (Nociception)?.Vitamin D Receptor (VDR) IS a Nuclear Transcription Factor.Vitamin D Absorption, Biosynthesis and Tissue Distribution.University of Illinois Chicago, United States TABLE OF CONTENTS